CJC-1295 (no DAC)
CJC-1295 without DAC, also sold as Mod GRF 1-29, is a lab-made copy of the first 29 amino acids of growth hormone–releasing hormone (GHRH), with four amino acids swapped. GHRH is the brain hormone that tells the pituitary to release growth hormone. It is a different molecule from CJC-1295 with DAC: it lacks the chemical add-on that binds that version to albumin in the blood and makes it last for days.
Approval status
Not approved as a medicine by FDA, EMA or other major regulators, and FDA found no human or animal studies of this exact molecule. Its compounding nominations were withdrawn, but FDA reviewed it anyway, and in December 2024 FDA's advisers voted against letting pharmacies compound it (13–0, and 12–1 for its acetate salt).82567
What it’s used or studied for
- Animal & lab only
In rat pituitary cells and pigs, closely related GHRH analogues with changes at the same positions (8, 15 and 27) were more stable and potent than natural GHRH.4
- No studies
Promoted online to raise growth hormone in short pulses, for muscle gain, fat loss, sleep and recovery. No published human studies have tested it.82
Each label shows how strong the evidence is: an approved use, human studies, animal or lab studies only, or a popular claim with no published studies. Being studied is not the same as being proven safe or effective.
Side effects
There are no published human safety data for this molecule. When FDA reviewed it in 2024, it found no clinical safety information on it.28
Cautions
- Often confused with CJC-1295 with DAC, a longer-acting molecule. FDA found the names used on products and in databases inconsistent.2
- FDA says pituitary overgrowth or tumors from long-term use cannot be ruled out, because the needed long-term animal studies have not been done.2
- FDA says compounded CJC-1295 may provoke immune reactions and is hard to characterize and keep free of impurities.6
- A forensic lab found seized doping products that held an altered version of modified GRF 1-29 with an extra amino acid (glycine).9
What it’s made of
- Type
- Peptide
- Length
- 29 amino acids
- Sequence
- Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg
- Modifications
- D-Ala at position 2, Gln at 8, Ala at 15 and Leu at 27 (natural GHRH has Ala, Asn, Gly and Met there); C-terminal amide; no DAC (no extra lysine or maleimide linker)
- Formula
- C152H252N44O42
- Molar mass
- 3367.9 g/mol
Made by chemical synthesis. FDA says it appears to have first been described in 2010, when a Norwegian doping lab identified it in an unknown seized preparation; the peptide was being marketed as CJC-1295.1234
This page summarizes published information. It is not medical advice and doesn’t recommend using any compound. Many of these compounds are sold for research only. Talk to a licensed clinician.
Sources
- PubChem: CJC-1295 without DAC (CID 56841945)
- FDA briefing document: CJC-1295-related bulk drug substances (Pharmacy Compounding Advisory Committee, December 4, 2024)
- Henninge J et al. Identification of CJC-1295 in an unknown pharmaceutical preparation (Drug Test Anal, 2010)
- Campbell RM et al. Enhanced stability and potency of novel GRF analogues (Peptides, 1994)
- FDA: Final summary minutes, Pharmacy Compounding Advisory Committee, December 4, 2024
- FDA: Certain bulk drug substances for use in compounding that may present significant safety risks (Category 2)
- WADA 2026 Prohibited List
- Dominikowski A et al. Performance-enhancing peptides modulating the GH-IGF1 axis: clinical evidence vs self-administration (Front Endocrinol, 2026)
- Gajda PM et al. Glycine-modified growth hormone secretagogues identified in seized doping material (Drug Test Anal, 2019)
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