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Adipotide

Adipotide (FTPP; called Prohibitin-TP01 in its human trial) is a lab-designed peptide meant to kill the blood vessels that feed white fat. One part homes to prohibitin, a protein on the vessels of fat tissue; the other part makes those cells die. It caused weight loss in obese mice and monkeys but injured the kidneys in monkeys. Its only human trial was stopped early and no results were published.

Not approved · research onlyWADA Not named; as an unapproved drug it falls under S0 (prohibited at all times)Checked October 2026
Open the Adipotide calculatorSources

Approval status

Not approved anywhere. The only human trial, a first-in-human study at MD Anderson in men with obesity and advanced prostate cancer, enrolled 4 people and was terminated at the investigator's request; no results have been posted.46

What it’s used or studied for

  • Animal & lab only

    Caused rapid weight loss and a marked drop in white fat in obese monkeys; the monkeys also ate less. Lean monkeys did not lose weight.3

  • Animal & lab only

    Improved insulin resistance in obese monkeys, and improved glucose tolerance in obese mice within days.35

  • Animal & lab only

    Reversed diet-induced obesity in mice by destroying blood vessels in white fat.2

Each label shows how strong the evidence is: an approved use, human studies, animal or lab studies only, or a popular claim with no published studies. Being studied is not the same as being proven safe or effective.

Side effects

No human safety results have been published. In monkeys the main toxicity was dose-dependent injury to the kidney tubules, with more urine, sugar and protein in the urine, and mild dehydration at the highest doses; most changes reversed after stopping.34

What it’s made of

Type
Peptide
Length
25 amino acids
Sequence
Cys-Lys-Gly-Gly-Arg-Ala-Lys-Asp-Cys-Gly-Gly-Lys-Leu-Ala-Lys-Leu-Ala-Lys-Lys-Leu-Ala-Lys-Leu-Ala-Lys
Modifications
Amino acids 12–25, (KLAKLAK)2, are D-amino acids; studies describe the Cys1–Cys9 targeting part as a ring (PubChem's record draws the two cysteines unlinked)
Formula
C111H206N36O28S2
Molar mass
2557.2 g/mol

Lab-designed. A fat-vessel-homing motif (CKGGRAKDC) found by phage display is joined by two glycines to a cell-killing D-(KLAKLAK)2 peptide.123

This page summarizes published information. It is not medical advice and doesn’t recommend using any compound. Many of these compounds are sold for research only. Talk to a licensed clinician.

Sources

  1. PubChem: Adipotide (CID 163360068)
  2. Kolonin MG et al. Reversal of obesity by targeted ablation of adipose tissue. Nat Med. 2004
  3. Barnhart KF et al. A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys. Sci Transl Med. 2011
  4. ClinicalTrials.gov NCT01262664: First-in-man phase I evaluation of prohibitin targeting peptide 1 in patients with metastatic prostate cancer and obesity
  5. Kim DH et al. Rapid and weight-independent improvement of glucose tolerance induced by a peptide designed to elicit apoptosis in adipose tissue endothelium. Diabetes. 2012
  6. WADA 2026 Prohibited List

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